Immunohistochemistry and flow cytometry were used to measure CD47 ("don't eat me signal") expression on tumor cells and characterize macrophages in the tumor microenvironment. In vitro engulfment assays and mouse experiments were performed with CD47-blocking antibodies to assess macrophage engulfment of tumor cells, progression of micrometastases in the liver and mouse survival.

CD47 participates in tumor immune escape by combining with SIRPα in other cancers, such as glioblastoma, 42 leiomyosarcoma, 43 osteosarcoma, 44 malignant mesothelioma, 24,45 non-Hodgkin’s lymphoma, 46 cervical cancer, ovarian cancer, renal cell carcinoma, 47–49 and bladder tumor. 50 Given that CD47 is widely expressed in various cancer types, it represents a potential and widely applicable …

CD47, SIRPα, immunotherapy, tumor microenvironment, pediatric cancer, innate immune system, checkpoint inhibitor, phagocytosis  Mar 30, 2020 antibodies to block CD47, a “don't eat me” signal on cancer cells, presently in development;; and immunotherapy drugs that block the PD-1  CD47, Do not eat me signal, Macrophage, Phagocytosis, Immunotherapy. Cells of the innate and adaptive arm of the immune system including macrophages,  Tumor cells express CD47, which can interact with the macrophages' SIRPα in the TME is well demonstrated in tumor progression and immunotherapy [5, 14]. Nov 1, 2018 Abstract Background The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune checkpoint inhibitor blocking CD47 that induces  Oct 15, 2014 CD47, a multi-facetted target for cancer immunotherapy Further, cross-linking of CD47 expressed on tumor cells via e.g. TSP-1 can directly  Nov 21, 2018 STANFORD, CA (US), November 2018 — A novel immunotherapy appears safe for use in patients with a type of blood cancer called  Mar 4, 2019 In particular, cell surface expression of the CD47 protein creates a 'don't Weiskopf, K. Cancer immunotherapy targeting the CD47/SIRPα axis.

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Author information: (1)Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. 2017-02-14 · Here, a surgical debulking GBM xenograft model was developed in nude rats, and was used in combination with CD47 blocking immunotherapy, a novel treatment strategy that triggers phagocytosis of tumor cells by macrophages in diverse cancer types including GBM. 2021-03-17 · Anti-CD47/PD-L1 immunotherapies aiming to enhance antitumor immunity are being intensively investigated and show promising results in cancer therapy; however, not all patients treated with these Se hela listan på frontiersin.org The researchers suggest that gut bacteria can penetrate tumor cells and boost the effectiveness of experimental immunotherapy that targets the CD47 protein. Methods CD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using human and mouse TNBC preclinical models, we evaluated the efficacy of PrCR-based immunotherapy by blocking CD47. 2020-04-02 · CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα.

2020-06-24 Cancer immunotherapy aims to re-activate the patients’ immune system for the elimination of cancer cells. It is currently a major focus of oncology research, and the results have shown impressive clinical efficacies. Among the various approaches to immunotherapy, the targeting of CD47 has been a subject of intense interest.

Mar 30, 2020 antibodies to block CD47, a “don't eat me” signal on cancer cells, presently in development;; and immunotherapy drugs that block the PD-1 

In vitro engulfment assays and mouse experiments were performed with CD47-blocking antibodies to assess macrophage engulfment of tumor cells, progression of micrometastases in the liver and mouse survival. As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response.

offers a valuable resource for researchers in the cancer immunotherapy field, checkpoint regulation and develop safer and more effective immunotherapies.

Jul 23, 2014 Immunotherapy – BLTA:HVEM, CD47:SIRPα in drug discovery. The treatment of diseases by inducing, enhancing, or surpressing an immune  Oct 1, 2018 CD47 has been found to be present on leukemic stem cells, but not on normal Is CD47 a good target for immunotherapy in lymphoma? Agonist Immunotherapy Targets and Combination Therapies, 15-16 Nov 2018, and has demonstrated superior activity compared to CD47/CD40 antibody  Feb 4, 2020 18Background: Magrolimab (M, Hu5F9-G4) is an antibody targeting CD47, a “ don't eat me” signal for macrophages that enhances ovarian  CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages. Immunotherapy is treatment that uses your body's own immune system to help fight cancer. Get information about the different types of immunotherapy and the  Nov 2, 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune  What are monoclonal antibodies and tumor-agnostic treatments? · Ipilimumab ( Yervoy) · Nivolumab (Opdivo) · Pembrolizumab (Keytruda) · Atezolizumab ( Tecentriq). Immunotherapy is a dramatic shift in how we fight cancer.

The treatment of diseases by inducing, enhancing, or surpressing an immune  Oct 1, 2018 CD47 has been found to be present on leukemic stem cells, but not on normal Is CD47 a good target for immunotherapy in lymphoma? Agonist Immunotherapy Targets and Combination Therapies, 15-16 Nov 2018, and has demonstrated superior activity compared to CD47/CD40 antibody  Feb 4, 2020 18Background: Magrolimab (M, Hu5F9-G4) is an antibody targeting CD47, a “ don't eat me” signal for macrophages that enhances ovarian  CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages. Immunotherapy is treatment that uses your body's own immune system to help fight cancer. Get information about the different types of immunotherapy and the  Nov 2, 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma The Hu5F9-G4 (hereafter, 5F9) antibody is a macrophage immune  What are monoclonal antibodies and tumor-agnostic treatments?
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It acts as myeloid immune checkpoint and thus has prognostic and therapeutic implications. Areas covered : This review presents and discusses the currently available data on the prognostic role and therapeutic value of CD47 in gastrointestinal tumors. 2017-09-19 As important innate immune cells, macrophages play important roles in maintaining homeostasis, preventing pathogen invasion, resisting tumor cells and promoting adaptive immune response. CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion.

Murata Y(1), Saito Y(1), Kotani T(1), Matozaki T(1). Author information: (1)Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. 2017-02-14 · Here, a surgical debulking GBM xenograft model was developed in nude rats, and was used in combination with CD47 blocking immunotherapy, a novel treatment strategy that triggers phagocytosis of tumor cells by macrophages in diverse cancer types including GBM. 2021-03-17 · Anti-CD47/PD-L1 immunotherapies aiming to enhance antitumor immunity are being intensively investigated and show promising results in cancer therapy; however, not all patients treated with these Se hela listan på frontiersin.org The researchers suggest that gut bacteria can penetrate tumor cells and boost the effectiveness of experimental immunotherapy that targets the CD47 protein. Methods CD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance.
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Cancer immunology, immunotherapy : CII - 2014-01-01 CD47-deficient mice have decreased production of intestinal IgA following oral immunization but a 

Although cells of the myeloid lineage frequently infiltrate tumors and limit therapeutic success, currently approved immunotherapies primarily target tumor-infiltrating T and natural killer lymphocytes. The inhibitory receptor signal CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy. Murata Y(1), Saito Y(1), Kotani T(1), Matozaki T(1). Author information: (1)Division of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan. 2017-02-14 · Here, a surgical debulking GBM xenograft model was developed in nude rats, and was used in combination with CD47 blocking immunotherapy, a novel treatment strategy that triggers phagocytosis of tumor cells by macrophages in diverse cancer types including GBM. 2021-03-17 · Anti-CD47/PD-L1 immunotherapies aiming to enhance antitumor immunity are being intensively investigated and show promising results in cancer therapy; however, not all patients treated with these Se hela listan på frontiersin.org The researchers suggest that gut bacteria can penetrate tumor cells and boost the effectiveness of experimental immunotherapy that targets the CD47 protein. Methods CD47 is a critical self-protective “don’t eat me” signal on multiple human cancers against macrophage immunosurveillance. Using human and mouse TNBC preclinical models, we evaluated the efficacy of PrCR-based immunotherapy by blocking CD47.